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Crystal structure of the human T cell receptor CD3εγ heterodimer complexed to the therapeutic mAb OKT3
The CD3εγ heterodimer is essential for expression and function of the T cell receptor. The crystal structure of the human CD3εγ heterodimer is described to 2.1-Å resolution complexed with OKT3, a therapeutic mAb that not only activates and tolerizes mature T cells but also induces regulatory T cells...
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| Veröffentlicht in: | Proc Natl Acad Sci U S A |
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| Hauptverfasser: | , , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2004
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC419665/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15136729/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0402295101 |
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