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Crystal structure of the human T cell receptor CD3εγ heterodimer complexed to the therapeutic mAb OKT3
The CD3εγ heterodimer is essential for expression and function of the T cell receptor. The crystal structure of the human CD3εγ heterodimer is described to 2.1-Å resolution complexed with OKT3, a therapeutic mAb that not only activates and tolerizes mature T cells but also induces regulatory T cells...
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| Главные авторы: | , , , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
National Academy of Sciences
2004
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC419665/ https://ncbi.nlm.nih.gov/pubmed/15136729 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0402295101 |
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