Activation of human T cells by FcR nonbinding anti-CD3 mAb, hOKT3γ1(Ala-Ala)

Dimeric Fc receptor (FcR) nonbinding anti-CD3 antibodies have been developed to minimize toxicities associated with classical anti-CD3 monoclonal antibodies (e.g., OKT3). Studies with murine analogs of non-FcR–binding antibodies have shown reduced mitogenicity compared to OKT3. In a trial of an FcR...

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Huvudupphovsmän: Herold, Kevan C., Burton, Joshua B., Francois, Fleur, Poumian-Ruiz, Ena, Glandt, Mariela, Bluestone, Jeffrey A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Clinical Investigation 2003
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC151852/
https://ncbi.nlm.nih.gov/pubmed/12569167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200316090
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