Crystal structure of the human T cell receptor CD3εγ heterodimer complexed to the therapeutic mAb OKT3

The CD3εγ heterodimer is essential for expression and function of the T cell receptor. The crystal structure of the human CD3εγ heterodimer is described to 2.1-Å resolution complexed with OKT3, a therapeutic mAb that not only activates and tolerizes mature T cells but also induces regulatory T cells...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Kjer-Nielsen, Lars, Dunstone, Michelle A., Kostenko, Lyudmila, Ely, Lauren K., Beddoe, Travis, Mifsud, Nicole A., Purcell, Anthony W., Brooks, Andrew G., McCluskey, James, Rossjohn, Jamie
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2004
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC419665/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15136729/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0402295101
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