LpxC Inhibitors as New Antibacterial Agents and Tools for Studying Regulation of Lipid A Biosynthesis in Gram-Negative Pathogens

The problem of multidrug resistance in serious Gram-negative bacterial pathogens has escalated so severely that new cellular targets and pathways need to be exploited to avoid many of the preexisting antibiotic resistance mechanisms that are rapidly disseminating to new strains. The discovery of sma...

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Hauptverfasser: Tomaras, Andrew P., McPherson, Craig J., Kuhn, Michael, Carifa, Arlene, Mullins, Lisa, George, David, Desbonnet, Charlene, Eidem, Tess M., Montgomery, Justin I., Brown, Matthew F., Reilly, Usa, Miller, Alita A., O’Donnell, John P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Microbiology 2014
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4196226/
https://ncbi.nlm.nih.gov/pubmed/25271285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.01551-14
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