Inhibition of LpxC Protects Mice from Resistant Acinetobacter baumannii by Modulating Inflammation and Enhancing Phagocytosis

New treatments are needed for extensively drug-resistant (XDR) Gram-negative bacilli (GNB), such as Acinetobacter baumannii. Toll-like receptor 4 (TLR4) was previously reported to enhance bacterial clearance of GNB, including A. baumannii. However, here we have shown that 100% of wild-type mice vers...

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Detalhes bibliográficos
Main Authors: Lin, Lin, Tan, Brandon, Pantapalangkoor, Paul, Ho, Tiffany, Baquir, Beverlie, Tomaras, Andrew, Montgomery, Justin I., Reilly, Usa, Barbacci, Elsa G., Hujer, Kristine, Bonomo, Robert A., Fernandez, Lucia, Hancock, Robert E. W., Adams, Mark D., French, Samuel W., Buslon, Virgil S., Spellberg, Brad
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Microbiology 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3518917/
https://ncbi.nlm.nih.gov/pubmed/23033474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.00312-12
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