Inhibition of LpxC Increases Antibiotic Susceptibility in Acinetobacter baumannii

LpxC inhibitors have generally shown poor in vitro activity against Acinetobacter baumannii. We show that the LpxC inhibitor PF-5081090 inhibits lipid A biosynthesis, as determined by silver staining and measurements of endotoxin levels, and significantly increases cell permeability. The presence of...

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Vydáno v:Antimicrob Agents Chemother
Hlavní autoři: García-Quintanilla, Meritxell, Caro-Vega, José M., Pulido, Marina R., Moreno-Martínez, Patricia, Pachón, Jerónimo, McConnell, Michael J.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2016
Témata:
Experimental Therapeutics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4958213/
https://ncbi.nlm.nih.gov/pubmed/27270288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00407-16
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