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Inhibition of LpxC Increases Antibiotic Susceptibility in Acinetobacter baumannii
LpxC inhibitors have generally shown poor in vitro activity against Acinetobacter baumannii. We show that the LpxC inhibitor PF-5081090 inhibits lipid A biosynthesis, as determined by silver staining and measurements of endotoxin levels, and significantly increases cell permeability. The presence of...
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| Publicado no: | Antimicrob Agents Chemother |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4958213/ https://ncbi.nlm.nih.gov/pubmed/27270288 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00407-16 |
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