LpxC Inhibitors as New Antibacterial Agents and Tools for Studying Regulation of Lipid A Biosynthesis in Gram-Negative Pathogens

The problem of multidrug resistance in serious Gram-negative bacterial pathogens has escalated so severely that new cellular targets and pathways need to be exploited to avoid many of the preexisting antibiotic resistance mechanisms that are rapidly disseminating to new strains. The discovery of sma...

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Detalhes bibliográficos
Main Authors: Tomaras, Andrew P., McPherson, Craig J., Kuhn, Michael, Carifa, Arlene, Mullins, Lisa, George, David, Desbonnet, Charlene, Eidem, Tess M., Montgomery, Justin I., Brown, Matthew F., Reilly, Usa, Miller, Alita A., O’Donnell, John P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Microbiology 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4196226/
https://ncbi.nlm.nih.gov/pubmed/25271285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.01551-14
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