Dual PI3K/mTOR inhibition is required to effectively impair microenvironment survival signals in mantle cell lymphoma

Phosphatidylinositol-3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) pathway activation contributes to mantle cell lymphoma (MCL) pathogenesis and drug resistance. Antitumor activity has been observed with mTOR inhibitors. However, they have shown limited clinical efficacy in relation to dr...

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Hlavní autoři: Rosich, Laia, Montraveta, Arnau, Xargay-Torrent, Sílvia, López-Guerra, Mónica, Roldán, Jocabed, Aymerich, Marta, Salaverria, Itziar, Beà, Sílvia, Campo, Elías, Pérez-Galán, Patricia, Roué, Gaël, Colomer, Dolors
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2014
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4196163/
https://ncbi.nlm.nih.gov/pubmed/25216518
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