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Structural insights by molecular dynamics simulations into specificity of the major human AP endonuclease toward the benzene-derived DNA adduct, pBQ-C

The benzetheno exocyclic adduct of the cytosine (C) base (pBQ-C) is a product of reaction between DNA and a stable metabolite of the human carcinogen benzene, p-benzoquinone (pBQ). We reported previously that the pBQ-C-containing duplex is a substrate for the human AP endonuclease (APE1), an enzyme...

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Autors principals: Guliaev, Anton B., Hang, Bo, Singer, B.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2004
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC419600/
https://ncbi.nlm.nih.gov/pubmed/15155853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkh594
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