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Structural insights by molecular dynamics simulations into specificity of the major human AP endonuclease toward the benzene-derived DNA adduct, pBQ-C

The benzetheno exocyclic adduct of the cytosine (C) base (pBQ-C) is a product of reaction between DNA and a stable metabolite of the human carcinogen benzene, p-benzoquinone (pBQ). We reported previously that the pBQ-C-containing duplex is a substrate for the human AP endonuclease (APE1), an enzyme...

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Bibliografske podrobnosti
izdano v:Nucleic Acids Res
Main Authors: Guliaev, Anton B., Hang, Bo, Singer, B.
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2004
Teme:
Online dostop:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC419600/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15155853/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/gkh594
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