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An unusual mechanism for the major human apurinic/apyrimidinic (AP) endonuclease involving 5′ cleavage of DNA containing a benzene-derived exocyclic adduct in the absence of an AP site

The major human apurinic/apyrimidinic (AP) endonuclease (class II) is known to cleave DNA 5′ adjacent to an AP site, which is probably the most common DNA damage produced hydrolytically or by glycosylase-mediated removal of modified bases. p-Benzoquinone (pBQ), one of the major benzene metabolites,...

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Bibliografski detalji
Glavni autori: Hang, B., Chenna, A., Fraenkel-Conrat, H., Singer, B.
Format: Artigo
Jezik:Inglês
Izdano: The National Academy of Sciences of the USA 1996
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC19409/
https://ncbi.nlm.nih.gov/pubmed/8943004
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