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Rescuing cystic fibrosis transmembrane conductance regulator (CFTR)-processing mutants by transcomplementation
Most cases of cystic fibrosis (CF) are caused by mutations that block the biosynthetic maturation of the CF gene product, the CF transmembrane conductance regulator (CFTR) chloride channel. CFTR-processing mutants fail to escape the endoplasmic reticulum and are rapidly degraded. Current efforts to...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2004
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC419584/ https://ncbi.nlm.nih.gov/pubmed/15141088 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0400459101 |
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