Rescuing cystic fibrosis transmembrane conductance regulator (CFTR)-processing mutants by transcomplementation

Most cases of cystic fibrosis (CF) are caused by mutations that block the biosynthetic maturation of the CF gene product, the CF transmembrane conductance regulator (CFTR) chloride channel. CFTR-processing mutants fail to escape the endoplasmic reticulum and are rapidly degraded. Current efforts to...

Fuld beskrivelse

Bibliografiske detaljer

Udgivet i:	Proc Natl Acad Sci U S A
Principais autores:	Cormet-Boyaka, Estelle, Jablonsky, Michael, Naren, Anjaparavanda P., Jackson, Patricia L., Muccio, Donald D., Kirk, Kevin L.
Format:	Artigo
Sprog:	Inglês
Udgivet:	National Academy of Sciences 2004
Fag:	Biological Sciences
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC419584/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15141088/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0400459101
Tags:	Tilføj Tag Ingen Tags, Vær først til at tagge denne postø!