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NuMA interacts with phosphoinositides and links the mitotic spindle with the plasma membrane

The positioning and the elongation of the mitotic spindle must be carefully regulated. In human cells, the evolutionary conserved proteins LGN/Gα(i1-3) anchor the coiled-coil protein NuMA and dynein to the cell cortex during metaphase, thus ensuring proper spindle positioning. The mechanisms governi...

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Sonraí Bibleagrafaíochta
Main Authors: Kotak, Sachin, Busso, Coralie, Gönczy, Pierre
Formáid: Artigo
Teanga:Inglês
Foilsithe: BlackWell Publishing Ltd 2014
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4195763/
https://ncbi.nlm.nih.gov/pubmed/24996901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201488147
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