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NuMA interacts with phosphoinositides and links the mitotic spindle with the plasma membrane

The positioning and the elongation of the mitotic spindle must be carefully regulated. In human cells, the evolutionary conserved proteins LGN/Gα(i1-3) anchor the coiled-coil protein NuMA and dynein to the cell cortex during metaphase, thus ensuring proper spindle positioning. The mechanisms governi...

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Autors principals: Kotak, Sachin, Busso, Coralie, Gönczy, Pierre
Format: Artigo
Idioma:Inglês
Publicat: BlackWell Publishing Ltd 2014
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4195763/
https://ncbi.nlm.nih.gov/pubmed/24996901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201488147
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