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NuMA interacts with phosphoinositides and links the mitotic spindle with the plasma membrane

The positioning and the elongation of the mitotic spindle must be carefully regulated. In human cells, the evolutionary conserved proteins LGN/Gα(i1-3) anchor the coiled-coil protein NuMA and dynein to the cell cortex during metaphase, thus ensuring proper spindle positioning. The mechanisms governi...

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Bibliographic Details
Main Authors: Kotak, Sachin, Busso, Coralie, Gönczy, Pierre
Format: Artigo
Language:Inglês
Published: BlackWell Publishing Ltd 2014
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4195763/
https://ncbi.nlm.nih.gov/pubmed/24996901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201488147
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