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Computational design of receptors for an organophosphate surrogate of the nerve agent soman

We report the computational design of soluble protein receptors for pinacolyl methyl phosphonic acid (PMPA), the predominant hydrolytic product of the nerve agent soman. Using recently developed computational protein design techniques, the ligand-binding pockets of two periplasmic binding proteins,...

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書誌詳細
主要な著者: Allert, Malin, Rizk, Shahir S., Looger, Loren L., Hellinga, Homme W.
フォーマット: Artigo
言語:Inglês
出版事項: National Academy of Sciences 2004
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC419530/
https://ncbi.nlm.nih.gov/pubmed/15148405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0401309101
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