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Local encoding of computationally designed enzyme activity

One aim of computational protein design is to introduce novel enzyme activity into proteins of known structure by predicting mutations that stabilize transition states. Previously we have shown that it is possible to introduce triose phosphate isomerase activity into the ribose-binding protein of Es...

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Bibliografiske detaljer
Main Authors: Allert, Malin, Dwyer, Mary A., Hellinga, Homme W.
Format: Artigo
Sprog:Inglês
Udgivet: 2006
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2963085/
https://ncbi.nlm.nih.gov/pubmed/17196220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2006.12.002
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