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The Fen1 extrahelical 3′-flap pocket is conserved from archaea to human and regulates DNA substrate specificity
Fen1 is a key enzyme for the maintenance of genetic stability in archaea and eukaryotes and is classified as a tumor suppressor. Very recent structural data obtained from Archaeoglobus fulgidus Fen1 suggest that an extrahelical 3′-flap pocket is responsible for substrate specificity, by binding to t...
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Oxford University Press
2004
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| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC419464/ https://ncbi.nlm.nih.gov/pubmed/15131255 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkh576 |
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