The human Rad9/Rad1/Hus1 damage sensor clamp interacts with DNA polymerase β and increases its DNA substrate utilisation efficiency: implications for DNA repair

In eukaryotic cells, checkpoints are activated in response to DNA damage. This requires the action of DNA damage sensors such as the Rad family proteins. The three human proteins Rad9, Rad1 and Hus1 form a heterotrimeric complex (called the 9-1-1 complex) that is recruited onto DNA upon damage. DNA...

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Main Authors: Toueille, Magali, El-Andaloussi, Nazim, Frouin, Isabelle, Freire, Raimundo, Funk, Dorothee, Shevelev, Igor, Friedrich-Heineken, Erica, Villani, Giuseppe, Hottiger, Michael O., Hübscher, Ulrich
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2004
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC443528/
https://ncbi.nlm.nih.gov/pubmed/15314187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkh652
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