The interaction site of Flap Endonuclease-1 with WRN helicase suggests a coordination of WRN and PCNA

Werner and Bloom syndromes are genetic RecQ helicase disorders characterized by genomic instability. Biochemical and genetic data indicate that an important protein interaction of WRN and Bloom syndrome (BLM) helicases is with the structure-specific nuclease Flap Endonuclease 1 (FEN-1), an enzyme th...

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Main Authors: Sharma, Sudha, Sommers, Joshua A., Gary, Ronald K., Friedrich-Heineken, Erica, Hübscher, Ulrich, Brosh, Robert M.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2005
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1301591/
https://ncbi.nlm.nih.gov/pubmed/16326861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gki1002
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