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Delineation of WRN Helicase Function with EXO1 in the Replicational Stress Response
The WRN gene defective in the premature aging disorder Werner syndrome encodes a helicase/exonuclease. We examined the ability of WRN to rescue DNA damage sensitivity of a yeast mutant defective in the Rad50 subunit of Mre11-Rad50- Xrs2 nuclease complex implicated in homologous recombination repair....
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2893289/ https://ncbi.nlm.nih.gov/pubmed/20447876 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2010.03.014 |
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