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The flexible loop of human FEN1 endonuclease is required for flap cleavage during DNA replication and repair
The conserved, structure-specific flap endonuclease FEN1 cleaves 5′ DNA flaps that arise during replication or repair. To address in vivo mechanisms of flap cleavage, we developed a screen for human FEN1 mutants that are toxic when expressed in yeast. Two targets were revealed: the flexible loop dom...
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| Autores principales: | , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Oxford University Press
2002
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC131084/ https://ncbi.nlm.nih.gov/pubmed/12411510 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdf587 |
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