Wird geladen...

The 3′→5′ exonuclease of DNA polymerase δ can substitute for the 5′ flap endonuclease Rad27/Fen1 in processing Okazaki fragments and preventing genome instability

Many DNA polymerases (Pol) have an intrinsic 3′→5′ exonuclease (Exo) activity which corrects polymerase errors and prevents mutations. We describe a role of the 3′→5′ Exo of Pol δ as a supplement or backup for the Rad27/Fen1 5′ flap endonuclease. A yeast rad27 null allele was lethal in combination w...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Jin, Yong Hwan, Obert, Robyn, Burgers, Peter M. J., Kunkel, Thomas A., Resnick, Michael A., Gordenin, Dmitry A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The National Academy of Sciences 2001
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC33174/
https://ncbi.nlm.nih.gov/pubmed/11309502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.091095198
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!