The 3′→5′ exonuclease of DNA polymerase δ can substitute for the 5′ flap endonuclease Rad27/Fen1 in processing Okazaki fragments and preventing genome instability

Many DNA polymerases (Pol) have an intrinsic 3′→5′ exonuclease (Exo) activity which corrects polymerase errors and prevents mutations. We describe a role of the 3′→5′ Exo of Pol δ as a supplement or backup for the Rad27/Fen1 5′ flap endonuclease. A yeast rad27 null allele was lethal in combination w...

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Publicat a:	Proc Natl Acad Sci U S A
Autors principals:	Jin, Yong Hwan, Obert, Robyn, Burgers, Peter M. J., Kunkel, Thomas A., Resnick, Michael A., Gordenin, Dmitry A.
Format:	Artigo
Idioma:	Inglês
Publicat:	National Academy of Sciences 2001
Matèries:	Biological Sciences
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC33174/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11309502/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.091095198
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