N-Succinimidyl guanidinomethyl iodobenzoate protein radiohalogenation agents: Influence of isomeric substitution on radiolabeling and target cell residualization

INTRODUCTION: N-succinimidyl 4-guanidinomethyl-3-[*I]iodobenzoate ([*I]SGMIB) has shown promise for the radioiodination of monoclonal antibodies (mAbs) and other proteins that undergo extensive internalization after receptor binding, enhancing tumor targeting compared to direct electrophilic radioio...

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Main Authors: Choi, Jaeyeon, Vaidyanathan, Ganesan, Koumarianou, Eftychia, McDougald, Darryl, Pruszynski, Marek, Osada, Takuya, Lahoutte, Tony, Lyerly, H. Kim, Zalutsky, Michael R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4192079/
https://ncbi.nlm.nih.gov/pubmed/25156548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nucmedbio.2014.07.005
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