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Astatine-211 Labeled Anti-HER2 5F7 Single Domain Antibody Fragment Conjugates: Radiolabeling and Preliminary Evaluation

INTODUCTION: Derived from heavy chain only camelid antibodies, ~15-kDa single-domain antibody fragments (sdAbs) are an attractive platform for developing molecularly specific imaging probes and targeted radiotherapeutics. The rapid tumor accumulation and normal tissue clearance of sdAbs might be ide...

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Detalhes bibliográficos
Publicado no:Nucl Med Biol
Main Authors: Choi, Jaeyeon, Vaidyanathan, Ganesan, Koumarianou, Eftychia, Kang, Choong Mo, Zalutsky, Michael R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5732883/
https://ncbi.nlm.nih.gov/pubmed/29031230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nucmedbio.2017.09.003
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