Improved Tumor Targeting of Anti-HER2 Nanobody Through N-Succinimidyl 4-Guanidinomethyl-3-Iodobenzoate Radiolabeling

Nanobodies are approximately 15-kDa proteins based on the smallest functional fragments of naturally occurring heavy chain–only antibodies and represent an attractive platform for the development of molecularly targeted agents for cancer diagnosis and therapy. Because the human epidermal growth fact...

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Hauptverfasser: Pruszynski, Marek, Koumarianou, Eftychia, Vaidyanathan, Ganesan, Revets, Hilde, Devoogdt, Nick, Lahoutte, Tony, Lyerly, H. Kim, Zalutsky, Michael R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4157601/
https://ncbi.nlm.nih.gov/pubmed/24578241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2967/jnumed.113.127100
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