FGF21 Acts Centrally to Induce Sympathetic Nerve Activity, Energy Expenditure and Weight Loss

The mechanism by which pharmacologic administration of the hormone FGF21 increases energy expenditure to cause weight loss in obese animals is unknown. Here we report that FGF21 acts centrally to exert its effects on energy expenditure and body weight in obese mice. Using tissue-specific knockout mi...

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Detalhes bibliográficos
Main Authors: Owen, Bryn M., Ding, Xunshan, Morgan, Donald A., Coate, Katie Colbert, Bookout, Angie L., Rahmouni, Kamal, Kliewer, Steven A., Mangelsdorf, David J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4192037/
https://ncbi.nlm.nih.gov/pubmed/25130400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2014.07.012
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