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FGF21 Acts Centrally to Induce Sympathetic Nerve Activity, Energy Expenditure and Weight Loss

The mechanism by which pharmacologic administration of the hormone FGF21 increases energy expenditure to cause weight loss in obese animals is unknown. Here we report that FGF21 acts centrally to exert its effects on energy expenditure and body weight in obese mice. Using tissue-specific knockout mi...

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書誌詳細
主要な著者: Owen, Bryn M., Ding, Xunshan, Morgan, Donald A., Coate, Katie Colbert, Bookout, Angie L., Rahmouni, Kamal, Kliewer, Steven A., Mangelsdorf, David J.
フォーマット: Artigo
言語:Inglês
出版事項: 2014
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4192037/
https://ncbi.nlm.nih.gov/pubmed/25130400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2014.07.012
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