FGF21 Acts Centrally to Induce Sympathetic Nerve Activity, Energy Expenditure and Weight Loss

The mechanism by which pharmacologic administration of the hormone FGF21 increases energy expenditure to cause weight loss in obese animals is unknown. Here we report that FGF21 acts centrally to exert its effects on energy expenditure and body weight in obese mice. Using tissue-specific knockout mi...

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Autori principali: Owen, Bryn M., Ding, Xunshan, Morgan, Donald A., Coate, Katie Colbert, Bookout, Angie L., Rahmouni, Kamal, Kliewer, Steven A., Mangelsdorf, David J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4192037/
https://ncbi.nlm.nih.gov/pubmed/25130400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2014.07.012
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