FGF19, FGF21 and an FGFR1/β-Klotho-activating Antibody Act on the Nervous System to Regulate Body Weight and Glycemia

Despite their different physiologic functions as hormonal regulators of fed and fasted metabolism, pharmacologic administration of FGF19 and FGF21 similarly cause increases in energy expenditure, weight loss and enhanced insulin sensitivity in obese animals. Here, in genetic loss-of-function studies...

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Bibliographische Detailangaben
Veröffentlicht in:Cell Metab
Hauptverfasser: Lan, Tian, Morgan, Donald A., Rahmouni, Kamal, Sonoda, Junichiro, Fu, Xiaorong, Burgess, Shawn C., Holland, William L., Kliewer, Steven A., Mangelsdorf, David J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5679468/
https://ncbi.nlm.nih.gov/pubmed/28988823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2017.09.005
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