βKlotho Is Required for Fibroblast Growth Factor 21 Effects On Growth and Metabolism

Fibroblast growth factor 21 (FGF21) is a fasting-induced hepatokine that has potent pharmacologic effects in mice, which include improving insulin sensitivity and blunting growth. The single-transmembrane protein, βKlotho, functions as a co-receptor for FGF21 in vitro. To determine if βKlotho is req...

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Main Authors: Ding, Xunshan, Boney-Montoya, Jamie, Owen, Bryn M., Bookout, Angie L., Coate, Katie Colbert, Mangelsdorf, David J., Kliewer, Steven A.
Format: Artigo
Jezik:Inglês
Izdano: 2012
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3447537/
https://ncbi.nlm.nih.gov/pubmed/22958921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2012.08.002
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