Beta-Amyloid Oligomers Activate Apoptotic BAK Pore for Cytochrome c Release

In Alzheimer’s disease, cytochrome c-dependent apoptosis is a crucial pathway in neuronal cell death. Although beta-amyloid (Aβ) oligomers are known to be the neurotoxins responsible for neuronal cell death, the underlying mechanisms remain largely elusive. Here, we report that the oligomeric form o...

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Hlavní autoři: Kim, Jaewook, Yang, Yoosoo, Song, Seung Soo, Na, Jung-Hyun, Oh, Kyoung Joon, Jeong, Cherlhyun, Yu, Yeon Gyu, Shin, Yeon-Kyun
Médium: Artigo
Jazyk:Inglês
Vydáno: The Biophysical Society 2014
Témata:
Membranes
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4190645/
https://ncbi.nlm.nih.gov/pubmed/25296312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2014.07.074
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