Amyloid-β oligomers may impair SNARE-mediated exocytosis by direct binding to syntaxin 1a

Alzheimer’s disease (AD) is closely associated with synaptic dysfunction and thus, current treatments often aim to stimulate neurotransmission to improve cognitive impairment. While the formation of the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complex is essentia...

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Bibliographic Details
Published in:Cell Rep
Main Authors: Yang, Yoosoo, Kim, Jaewook, Kim, Hye Yun, Ryoo, Nayeon, Lee, Sejin, Kim, YoungSoo, Rhim, Hyewhon, Shin, Yeon-Kyun
Format: Artigo
Language:Inglês
Published: 2015
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4955600/
https://ncbi.nlm.nih.gov/pubmed/26279571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.07.044
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