ABCC3 and OCT1 genotypes influence pharmacokinetics of morphine in children

AIM: Large interindividual variability in morphine pharmacokinetics could contribute to variability in morphine analgesia and adverse events. METHODS: Influence of weight, genetic polymorphisms, race and sex on morphine clearance and metabolite formation from 220 children undergoing outpatient adeno...

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Main Authors: Venkatasubramanian, Raja, Fukuda, Tsuyoshi, Niu, Jing, Mizuno, Tomoyuki, Chidambaran, Vidya, Vinks, Alexander A, Sadhasivam, Senthilkumar
Format: Artigo
Sprog:Inglês
Udgivet: 2014
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4190075/
https://ncbi.nlm.nih.gov/pubmed/25155932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2217/pgs.14.99
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