Structure of cohesin subcomplex pinpoints direct shugoshin–Wapl antagonism in centromeric cohesion

Orderly termination of sister-chromatid cohesion during mitosis is critical for accurate chromosome segregation. During prophase, mitotic kinases phosphorylate cohesin and its protector sororin, triggering Wapl-dependent cohesin release from chromosome arms. The shugoshin (Sgo1)–PP2A complex protect...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Hara, Kodai, Zheng, Ge, Qu, Qianhui, Liu, Hong, Ouyang, Zhuqing, Chen, Zhe, Tomchick, Diana R., Yu, Hongtao
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2014
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4190070/
https://ncbi.nlm.nih.gov/pubmed/25173175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2880
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