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IQGAP1 scaffold-kinase interaction blockade selectively targets RAS-MAP kinase–driven tumors
Upregulation of the ERK1 and ERK2 (ERK1/2) MAP kinase (MAPK) cascade occurs in >30% of cancers(1), often through mutational activation of receptor tyrosine kinases or other upstream genes, including KRAS and BRAF (2). Efforts to target endogenous MAPKs are challenged by the fact that these kinase...
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| 主要な著者: | , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2013
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4190012/ https://ncbi.nlm.nih.gov/pubmed/23603816 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3165 |
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