Computational Insights into Substrate and Site Specificities, Catalytic Mechanism, and Protonation States of the Catalytic Asp Dyad of β-Secretase

In this review, information regarding substrate and site specificities, catalytic mechanism, and protonation states of the catalytic Asp dyad of β-secretase (BACE1) derived from computational studies has been discussed. BACE1 catalyzes the rate-limiting step in the generation of Alzheimer amyloid be...

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Detalles Bibliográficos
Main Authors: Barman, Arghya, Prabhakar, Rajeev
Formato: Artigo
Idioma:Inglês
Publicado: Hindawi Publishing Corporation 2014
Assuntos:
Review Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4189502/
https://ncbi.nlm.nih.gov/pubmed/25309776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2014/598728
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