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Computational Insights into Substrate and Site Specificities, Catalytic Mechanism, and Protonation States of the Catalytic Asp Dyad of β-Secretase

In this review, information regarding substrate and site specificities, catalytic mechanism, and protonation states of the catalytic Asp dyad of β-secretase (BACE1) derived from computational studies has been discussed. BACE1 catalyzes the rate-limiting step in the generation of Alzheimer amyloid be...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Arghya Barman, Rajeev Prabhakar
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Hindawi Limited 2014-01-01
Saila:Scientifica
Sarrera elektronikoa:http://dx.doi.org/10.1155/2014/598728
Etiketak: Etiketa erantsi
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