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Klotho is a substrate for α-, β- and γ-secretase
Klotho is an anti-aging protein with different functions of the full-length membrane protein and the secreted hormone-like form. Using overexpression and knock-down approaches as well as embryonic fibroblasts of knock-out mice we present evidence that Klotho is shedded by the α-secretases ADAM10 and...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2757472/ https://ncbi.nlm.nih.gov/pubmed/19737556 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2009.09.009 |
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