A Genomic Signature Approach to Rescue ΔF508-Cystic Fibrosis Transmembrane Conductance Regulator Biosynthesis and Function

The most common cystic fibrosis (CF) mutation, ΔF508, causes protein misfolding, leading to proteosomal degradation. We recently showed that expression of miR-138 enhances CF transmembrane conductance regulator (CFTR) biogenesis and partially rescues ΔF508-CFTR function in CF airway epithelia. We hy...

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Detalhes bibliográficos
Principais autores: Ramachandran, Shyam, Osterhaus, Samantha R., Karp, Philip H., Welsh, Michael J., McCray, Paul B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Thoracic Society 2014
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4189493/
https://ncbi.nlm.nih.gov/pubmed/24669817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2014-0007OC
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