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SYVN1, NEDD8, and FBXO2 Proteins Regulate ΔF508 Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Ubiquitin-mediated Proteasomal Degradation

We previously reported that delivery of a microRNA-138 mimic or siRNA against SIN3A to cultured cystic fibrosis (ΔF508/ΔF508) airway epithelia partially restored ΔF508-cystic fibrosis transmembrane conductance regulator (CFTR)-mediated cAMP-stimulated Cl(−) conductance. We hypothesized that dissecti...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Ramachandran, Shyam, Osterhaus, Samantha R., Parekh, Kalpaj R., Jacobi, Ashley M., Behlke, Mark A., McCray, Paul B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5207249/
https://ncbi.nlm.nih.gov/pubmed/27756846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.754283
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