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Repair kinetics of acrolein– and (E)-4-hydroxy-2-nonenal–derived DNA adducts in human colon cell extracts
ω-3 and ω-6 Polyunsaturated fatty acids (PUFAs) play a role in the pathogenesis of colon cancer. Upon oxidation, PUFAs generate α,β-unsaturated aldehydes or enals, such as acrolein (Acr) and (E)-4-hydroxy-2-nonenal (HNE), which can form cyclic adducts of deoxyguanosine (Acr-dG and HNE-dG, respective...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4188536/ https://ncbi.nlm.nih.gov/pubmed/24113140 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mrfmmm.2013.09.004 |
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