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Detection of the Acrolein-derived Cyclic DNA Adduct by a Quantitative (32)P-postlabeling/Solid Phase Extraction/HPLC Method: Blocking its artifact formation by Glutathione
Acrolein (Acr), a hazardous air pollutant, reacts readily with deoxyguanosine (dG) in DNA to produce cyclic 1,N(2)-propanodeoxyguanosine adducts (Acr-dG). Studies show that these adducts are detected in vivo and may play a role in mutagenesis and carcinogenesis. In the present study, we developed a...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2275120/ https://ncbi.nlm.nih.gov/pubmed/18036548 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ab.2007.10.029 |
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