Nucleotide excision repair deficiency increases levels of acrolein-derived cyclic DNA adduct and sensitizes cells to apoptosis induced by docosahexaenoic acid and acrolein

The acrolein derived cyclic 1,N(2)-propanodeoxyguanosine adduct (Acr-dG), formed primarily from ω-3 polyunsaturated fatty acids such as docosahexaenoic acid (DHA) under oxidative conditions, while proven to be mutagenic, is potentially involved in DHA-induced apoptosis. The latter may contribute to...

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Publicado no:Mutat Res
Main Authors: Pan, Jishen, Sinclair, Elizabeth, Xuan, Zhuoli, Dyba, Marcin, Fu, Ying, Sen, Supti, Berry, Deborah, Creswell, Karen, Hu, Jiaxi, Roy, Rabindra, Chung, Fung-Lung
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5896306/
https://ncbi.nlm.nih.gov/pubmed/27036235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mrfmmm.2016.02.011
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