Nucleotide excision repair deficiency increases levels of acrolein-derived cyclic DNA adduct and sensitizes cells to apoptosis induced by docosahexaenoic acid and acrolein

The acrolein derived cyclic 1,N(2)-propanodeoxyguanosine adduct (Acr-dG), formed primarily from ω-3 polyunsaturated fatty acids such as docosahexaenoic acid (DHA) under oxidative conditions, while proven to be mutagenic, is potentially involved in DHA-induced apoptosis. The latter may contribute to...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:Mutat Res
Autori principali: Pan, Jishen, Sinclair, Elizabeth, Xuan, Zhuoli, Dyba, Marcin, Fu, Ying, Sen, Supti, Berry, Deborah, Creswell, Karen, Hu, Jiaxi, Roy, Rabindra, Chung, Fung-Lung
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
Soggetti:
Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5896306/
https://ncbi.nlm.nih.gov/pubmed/27036235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mrfmmm.2016.02.011
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi