Detection of the Acrolein-derived Cyclic DNA Adduct by a Quantitative (32)P-postlabeling/Solid Phase Extraction/HPLC Method: Blocking its artifact formation by Glutathione

Acrolein (Acr), a hazardous air pollutant, reacts readily with deoxyguanosine (dG) in DNA to produce cyclic 1,N(2)-propanodeoxyguanosine adducts (Acr-dG). Studies show that these adducts are detected in vivo and may play a role in mutagenesis and carcinogenesis. In the present study, we developed a...

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Main Authors: Emami, Armaghan, Dyba, Marcin, Cheema, Amrita K., Pan, Jishen, Nath, Raghu G., Chung, Fung-Lung
格式: Artigo
語言:Inglês
出版: 2007
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2275120/
https://ncbi.nlm.nih.gov/pubmed/18036548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ab.2007.10.029
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