HDAC6 Deacetylates and Ubiquitinates MSH2 to Maintain Proper Levels of MutSα

MutS protein homolog 2 (MSH2) is a key DNA mismatch repair protein. It forms the MSH2-MSH6 (MutSα) and MSH2-MSH3 (MutSβ) heterodimers, which help to ensure genomic integrity. MutSα not only recognizes and repairs mismatched nucleotides but also recognizes DNA adducts induced by DNA-damaging agents,...

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Main Authors: Zhang, Mu, Xiang, Shengyan, Joo, Heui-Yun, Wang, Lei, Williams, Kendra A., Liu, Wei, Hu, Chen, Tong, Dan, Haakenson, Joshua, Wang, Chuangui, Zhang, Shengping, Pavlovicz, Ryan E., Jones, Amanda, Schmidt, Kristina H., Tang, Jinfu, Dong, Huiqin, Shan, Bin, Fang, Bin, Radhakrishnan, Rangasudhagar, Glazer, Peter M., Matthias, Patrick, Koomen, John, Seto, Edward, Bepler, Gerold, Nicosia, Santo V., Chen, Jiandong, Li, Chenglong, Gu, Liya, Li, Guo-Min, Bai, Wenlong, Wang, Hengbin, Zhang, Xiaohong
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4188514/
https://ncbi.nlm.nih.gov/pubmed/24882211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2014.04.028
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