HDAC6 regulates DNA damage response via deacetylating MLH1

MutL homolog 1 (MLH1) is a key DNA mismatch repair protein, which plays an important role in maintenance of genomic stability and the DNA damage response. Here, we report that MLH1 is a novel substrate of histone deacetylase 6 (HDAC6). HDAC6 interacts with and deacetylates MLH1 both in vitro and in...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Zhang, Mu, Hu, Chen, Moses, Niko, Haakenson, Joshua, Xiang, Shengyan, Quan, Daniel, Fang, Bin, Yang, Zhe, Bai, Wenlong, Bepler, Gerold, Li, Guo-Min, Zhang, Xiaohong Mary
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2019
Assuntos:
Enzymology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6463726/
https://ncbi.nlm.nih.gov/pubmed/30770470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.006374
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