Effect of Coadministered Fat on the Tolerability, Safety, and Pharmacokinetic Properties of Dihydroartemisinin-Piperaquine in Papua New Guinean Children with Uncomplicated Malaria

Coadministration of dihydroartemisinin-piperaquine (DHA-PQ) with fat may improve bioavailability and antimalarial efficacy, but it might also increase toxicity. There have been no studies of these potential effects in the pediatric age group. The tolerability, safety, efficacy, and pharmacokinetics...

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Main Authors: Moore, B. R., Benjamin, J. M., Salman, S., Griffin, S., Ginny, E., Page-Sharp, M., Robinson, L. J., Siba, P., Batty, K. T., Mueller, I., Davis, T. M. E.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2014
Fag:
Clinical Therapeutics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4187992/
https://ncbi.nlm.nih.gov/pubmed/25049242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.03314-14
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