Pharmacokinetic Interaction between Pyronaridine-Artesunate and Metoprolol

The objectives of this study were to characterize any drug-drug interaction between the antimalarial Pyramax (pyronaridine-artesunate [PA]) and the CYP2D6 probe substrate metoprolol and to assess the safety of 60-day or 90-day PA redosing, particularly with regard to liver biochemistry parameters. H...

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Bibliographic Details
Main Authors: Morris, Carrie A., Pokorny, Rolf, Lopez-Lazaro, Luis, Miller, Robert M., Arbe-Barnes, Sarah, Duparc, Stephan, Borghini-Fuhrer, Isabelle, Shin, Jang-Sik, Fleckenstein, Lawrence
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2014
Subjects:
Pharmacology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4187956/
https://ncbi.nlm.nih.gov/pubmed/25070091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02716-14
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