Crystal Structure of the Extended-Spectrum β-Lactamase PER-2 and Insights into the Role of Specific Residues in the Interaction with β-Lactams and β-Lactamase Inhibitors

PER-2 belongs to a small (7 members to date) group of extended-spectrum β-lactamases. It has 88% amino acid identity with PER-1 and both display high catalytic efficiencies toward most β-lactams. In this study, we determined the X-ray structure of PER-2 at 2.20 Å and evaluated the possible role of s...

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Detalhes bibliográficos
Main Authors: Ruggiero, Melina, Kerff, Frédéric, Herman, Raphaël, Sapunaric, Frédéric, Galleni, Moreno, Gutkind, Gabriel, Charlier, Paulette, Sauvage, Eric, Power, Pablo
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Mechanisms of Resistance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4187900/
https://ncbi.nlm.nih.gov/pubmed/25070104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00089-14
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