Structural Insights into the Inhibition of the Extended-Spectrum β-Lactamase PER-2 by Avibactam

The diazabicyclooctane (DBO) avibactam (AVI) reversibly inactivates most serine-β-lactamases. Previous investigations showed that inhibition constants of AVI toward class A PER-2 are reminiscent of values observed for class C and D β-lactamases (i.e., k(2)/K of ≈10(3) M(−1) s(−1)) but lower than oth...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Ruggiero, Melina, Papp-Wallace, Krisztina M., Brunetti, Florencia, Barnes, Melissa D., Bonomo, Robert A., Gutkind, Gabriel, Klinke, Sebastián, Power, Pablo
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2019
Assuntos:
Mechanisms of Resistance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6709463/
https://ncbi.nlm.nih.gov/pubmed/31235626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00487-19
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados